解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A plastic optical fibre biosensor based on surface plasmon resonance for the detection of C-reactive protein (CRP) in serum is proposed. The biosensor was integrated into a home-made thermo-stabilized microfluidic system that allows avoiding any thermal and/or mechanical fluctuation and maintaining the best stable con...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500315
更新日期:2016-10-01 00:00:00
abstract::In vivo microscopy has recently become a gold standard in lung immunology studies involving small animals, largely benefiting from the democratization of multiphoton microscopy allowing for deep tissue imaging. This technology represents currently our only way of exploring the lungs and inferring what happens in human...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201500246
更新日期:2016-09-01 00:00:00
abstract::The aim of this study is to identify changes in scattering with optical coherence tomography (OCT) and relate these measurements with mitochondrial changes during the initiation of apoptosis. Human retinal pigment epithelial cells were cultured and apoptosis was induced using 10% alcohol. Using the attenuation coeffic...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500198
更新日期:2016-09-01 00:00:00
abstract::The broad range of applications of spatially-offset Raman spectroscopy (SORS) were found to involve samples having only marginal differences in Raman cross-sections between the surface and subsurface targets. We report the results of a feasibility study to evaluate the potential of the approach to identify the presenc...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600075
更新日期:2016-09-01 00:00:00
abstract::Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500206
更新日期:2016-09-01 00:00:00
abstract::A new optical scattering contrast-agent based on polymer-nanoparticle encapsulated silver nanoplates (PESNs) is presented. Silver nanoplates were chosen due to the flexibility of tuning their plasmon frequencies. The polymer coating preserves their physical and optical properties and confers other advantages such as c...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500177
更新日期:2016-07-01 00:00:00
abstract::Ectasia after refractive surgery represents a major concern among refractive surgeons. Corneal abnormalities and preexisting corneal ectasia are the most important risk factors. Corneal topography and central corneal thickness are the factors traditionally screening for in refractive surgery candidates. Study of the a...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500236
更新日期:2016-05-01 00:00:00
abstract::A novel hybrid method which combines sub-wavelength-scale phase measurements and pixel-scale displacement tracking for robust strain mapping in compressional optical coherence elastography is proposed. Unlike majority of OCE methods it does not rely on initial reconstruction of displacements and does not suffer from t...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500203
更新日期:2016-05-01 00:00:00
abstract::The paper presents a new algorithm based on some selected automatic quantitative methods for analysing thermal images. It shows the practical implementation of these image analysis methods in Matlab. It enables to perform fully automated and reproducible measurements of selected parameters in thermal images. The paper...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500224
更新日期:2016-05-01 00:00:00
abstract::The effect of cetyl-trimethylammonium bromide (CTAB) on enhancing the fluorescence resonance energy transfer (FRET) between two dye-conjugated DNA strands was studied using fluorescence emission spectroscopy and dynamic light scattering (DLS). For hybridized DNA where one strand is conjugated with a TAMRA donor and th...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500221
更新日期:2016-01-01 00:00:00
abstract::We report on transient membrane perforation of living cancer cells using plasmonic gold nanoparticles (AuNPs) enhanced single near infrared (NIR) femtosecond (fs) laser pulse. Under optimized laser energy fluence, single pulse treatment (τ = 45 fs, λ = 800 nm) resulted in 77% cell perforation efficiency and 90% cell v...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500135
更新日期:2016-01-01 00:00:00
abstract::Single-molecule localisation based super-resolution fluorescence imaging produces maps of the coordinates of fluorescent molecules in a region of interest. Cluster analysis algorithms provide information concerning the clustering characteristics of these molecules, often through the generation of cluster heat maps bas...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201400127
更新日期:2015-11-01 00:00:00
abstract::In vivo imaging of cerebral vasculature is highly vital for clinicians and medical researchers alike. For a number of years non-invasive optical-based imaging of brain vascular network by using standard fluorescence probes has been considered as impossible. In the current paper controverting this paradigm, we present ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201400140
更新日期:2015-11-01 00:00:00
abstract::Bacterial meningitis is a disease of pronounced clinical significance, especially in the developing world. Immediate treatment with antibiotics is essential, and no single test can provide a conclusive diagnosis. It is well established that elevated total protein in cerebrospinal fluid (CSF) is associated with bacteri...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201400047
更新日期:2015-05-01 00:00:00
abstract::Optical coherence elastography (OCE) represents the frontier of optical elasticity imaging techniques and focuses on the micro-scale assessment of tissue biomechanics in 3D that is hard to achieve with traditional elastographic methods. Benefit from the advancement of optical coherence tomography, and driven by the in...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201400108
更新日期:2015-04-01 00:00:00
abstract::The research work presented in this paper focuses on qualitative tissue differentiation by monitoring the intensity ratios of atomic emissions using 'Laser Induced Breakdown Spectroscopy' (LIBS) on the plasma plume created during laser tissue ablation. The background of this study is to establish a real time feedback ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300159
更新日期:2015-01-01 00:00:00
abstract::Currently, optical coherence tomography (OCT), is not capable of obtaining molecular information often crucial for identification of disease. To enable molecular imaging with OCT, we have further developed a technique that harnesses transient changes in light absorption in the sample to garner molecular information. A...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300119
更新日期:2015-01-01 00:00:00
abstract::Diffuse reflectance spectroscopy is a rapidly growing technology in the biophotonics community where it has shown promise in its ability to classify different tissues. In the steady-state domain a wide spectrum of clinical applications is supported with this technology ranging from diagnostic to guided interventions. ...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201300198
更新日期:2015-01-01 00:00:00
abstract::Several studies have demonstrated the potential of cross-polarization optical coherence tomography (CP-OCT) to quantify the severity of early caries lesions (tooth decay) on tooth surfaces. The purpose of this study is to show that 2D images of the lesion depth and the integrated reflectivity can be used to accurately...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300137
更新日期:2015-01-01 00:00:00
abstract::Surface-enhanced Raman scattering (SERS) spectroscopy possesses the most promising advantage of multiplex detection for biosensing applications, which is achieved due to the narrow 'fingerprint' Raman spectra from the analyte molecules. We developed an ultrasensitive platform for the multiplex detection of cancer biom...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300084
更新日期:2014-11-01 00:00:00
abstract::Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca(2+) transients. The higher Ca(2+) peaks were observed at lower laser doses, with the hi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300043
更新日期:2014-10-01 00:00:00
abstract::Dynamic follow-up of exogenous molecules permeation through the skin is one among many competing applications for confocal Raman microspectroscopy. Previous studies showed the feasibility of tracking actives through the skin; the next step should be recording in vivo kinetics. Thus, we conducted a study to evaluate th...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300011
更新日期:2014-09-01 00:00:00
abstract::Semen analysis is performed for evaluation of fertility disorders, however it is susceptible to subjectivity of investigators, and lacking of objective criterion for sperm cell quality remains a problem. There is an ongoing debate on which criteria should be employed to define normal spermatozoa. Here, the aim of our ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300003
更新日期:2014-09-01 00:00:00
abstract::The use of conventional fluorescence microscopy for characterizing tissue pathological states is limited by overlapping spectra and the dependence on excitation power and fluorophore concentration. Fluorescence lifetime imaging microscopy (FLIM) can overcome these limitations due to its insensitivity to fluorophore co...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200202
更新日期:2014-07-01 00:00:00
abstract::In biomedical applications, nanoparticles have demonstrated the potential to eradicate abnormal cells in small localized pathological zones associated with cancer or infections. Here, we introduce a method for nanotechnology-based photothermal (PT) killing of whole organisms considered harmful to humans or the environ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200199
更新日期:2014-07-01 00:00:00
abstract::FTIR spectroscopy is a powerful diagnostic tool that can also derive biochemical signatures of a wide range of cellular materials, such as cytology, histology, live cells, and biofluids. However, while classification is a well-established subject, biomarker identification lacks standards and validation of its methods....
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300190
更新日期:2014-04-01 00:00:00
abstract::FTIR microspectroscopy was applied for studying macromolecular changes in human serum samples from patients with healthy livers, and those diagnosed with liver cirrhosis or hepatocellular carcinoma (HCC). Our study demonstrated that the serum samples from HCC and cirrhotic patients could readily be discriminated from ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300183
更新日期:2014-04-01 00:00:00
abstract::Bone-marrow (BM)-derived cells have been shown to be capable of aiding skin regeneration in vivo by differentiating into keratinocytes. However, the conditions under which this occurs are not fully understood. Characterizing innate mechanisms of skin regeneration by stem cells in vivo is important for the area of stem...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200240
更新日期:2014-01-01 00:00:00
abstract::We have investigated the ability of dual-frequency Coherent Antistokes Raman Scattering (D-CARS) micro-spectroscopy, based on femtosecond pulses (100 fs or 5 fs) spectrally focussed by glass dispersion, to distinguish the chemical composition of micron-sized lipid droplets consisting of different triglycerides types (...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200197
更新日期:2014-01-01 00:00:00
abstract::A simple scheme for multimodal coherent anti-Stokes Raman scattering (CARS) microscopy is based on the spectral focusing of ultrafast-oscillator-derived pump/probe light and synchronous photonic crystal fiber (PCF) fiber-generated broadband Stokes light. To date, such schemes allowed rapid hyperspectral imaging throug...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200171
更新日期:2014-01-01 00:00:00
abstract::We present a novel silicon photonic biosensor using phase-shifted Bragg gratings in a slot waveguide. The optical field is concentrated inside the slot region, leading to efficient light-matter interaction. The Bragg gratings are formed with sidewall corrugations on the outside of the waveguide, and a phase shift is i...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300012
更新日期:2013-10-01 00:00:00
abstract::Stimulated Raman scattering (SRS) has been applied to unstained samples of articular cartilage enabling the investigation of living cells within fresh tissue. Hyperspectral SRS measurements over the CH vibrational region showed variations in protein and lipid content within the cells, pericellular matrix and interterr...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200213
更新日期:2013-10-01 00:00:00
abstract::We introduce a unique method for laser-propelling individual cells over distances of 10s of cm through stationary liquid in a microfluidic channel. This is achieved by using liquid-filled hollow-core photonic crystal fiber (HC-PCF). HC-PCF provides low-loss light guidance in a well-defined single mode, resulting in hi...
journal_title:Journal of biophotonics
pub_type: 社论
doi:10.1002/jbio.201200180
更新日期:2013-09-01 00:00:00
abstract::We present the design and construction of a prototype imaging probe capable of co-registered pulse-echo ultrasound and photoacoustic (optoacoustic) imaging in real time. The probe consists of 36 fibers of 200 micron core diameter each that are distributed around a commercial transvaginal ultrasound transducer, and hou...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200163
更新日期:2013-06-01 00:00:00
abstract::We fabricated composite nanoparticles consisting of a plasmonic core (gold nanorods or gold-silver nanocages) and a hematoporphyrin-doped silica shell. The dual photodynamic and photothermal activities of such nanoparticles against Staphylococcus aureus 209 P were studied and compared with the activities of reference ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200079
更新日期:2013-04-01 00:00:00
abstract::Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. Here, we develop and compare different approaches for developing Raman classification algorithms to diagnose invasive and in situ breast cancer, fibrocystic change and fibroadenoma that can be associ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200098
更新日期:2013-04-01 00:00:00
abstract::Semiconductor nanoparticles (NPs) became important and wide-used tool for cell imaging because of their unique remarkable properties. Nevertheless, all previous investigations in this area were done on proliferating cells. For the first time, this work demonstrates strong influence of cell active proliferation/contact...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200066
更新日期:2013-03-01 00:00:00
abstract::The investigation of lung dynamics on alveolar scale is crucial for the understanding and treatment of lung diseases, such as acute lung injury and ventilator induced lung injury, and to promote the development of protective ventilation strategies. One approach to this is the establishment of numerical simulations of ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200027
更新日期:2013-02-01 00:00:00
abstract::We report a compact, cost-effective tuned amplifier for frequency-selective amplification of the modulated signal in heterodyne detected nonlinear optical microscopy. Our method improved the signal to noise ratio by an order of magnitude compared to conventional lock-in detection, as demonstrated through stimulated Ra...
journal_title:Journal of biophotonics
pub_type: 社论
doi:10.1002/jbio.201200005
更新日期:2012-10-01 00:00:00
abstract::Nanofluidics enables the imaging of stretched single molecules with potential applications for single molecule sequence mapping. Lab-on-a-chip devices for single cell trapping and lyzing, genomic DNA extraction from single cells, and optical mapping of genomic length DNA has been demonstrated separately. Yet the pursu...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201200050
更新日期:2012-08-01 00:00:00